Molecular Variation in Proteins

摘要: Publisher Summary This chapter describes the molecular variation in proteins. The simplest cause that may produce a change amino acid sequence of polypeptide chain is point mutation due to substitution single base codon triplet for affected by replacement. For instance, valine residue one glutamic acid, at position 6 HbS variant hemoglobin-A, caused replacement adenine uridine second triplet. From organization genetic code, it will be appreciated certain substitutions require more than and, hence, are less likely occur. probability such maintain itself during evolution is, however, solely determined its effect upon functional fitness corresponding chain. classical example isotypic because development gene cluster furnished hemoglobins