Alignment of human cardiomyocytes on laser patterned biphasic core/shell nanowire assemblies.

摘要: The management of end stage heart failure patients is only possible by transplantation or the implantation artificial hearts as a bridge for later transplantation. However, these therapeutic strategies are limited lack donor and associated complications, such coagulation infection, due to used mechanical circulatory assist devices. Therefore, new myocardial regenerative approaches under extensive research produce contractile tissue in future replace non-contractile ischemic scarred tissue. Different approaches, cell transplantation, have been studied intensively. Although successful observed, there still limitations application. It envisaged that engineering can be help infarcted developed should mimic aligned fibrillar structure extracellular matrix provide important guidance cues survival, function needed orientation cardiomyocytes. Nanostructured surfaces tested guided direction cells follow. In present study, cellular adhesion/alignment human cardiomyocytes biocompatibility investigated after cultivation on different laser-patterned nanowires compared with unmodified nanowires. As result, nanostructured possessed good before laser modification. laser-induced scalability pattern enabled growth adhered Such may modify surface potential scaffolds develop future.