Inhibition and Regression of Experimental Oral Cancer by Beta Carotene and Vitamin E: Emerging Concepts

摘要: The hamster buccal pouch experimental model for oral cancer has proven to be a superior mucosal carcinogenesis and is now receiving wide attention as one of the better overall models carcinogenesis. malignant tumors are epidermoid carcinomas that develop slowly, in response polyaromatic hydrocarbon carcinogen application, preceded by keratotic dysplastic lesion comparable human precancerous leukoplakia. lesions indistinguishable histologically from well-to-moderately differentiated variety, at both light microscopic ultrastructural levels. Both animal have similar metabolic markers, such asgamma glutamyl transpeptidase (GGT) lactic dehydrogenase. carcinoma develops with activation expression specific oncogenes, often those expressed cancer. These include c-erbBl, H-ras, K-ras, mutant p53. clearly visible all times can counted measured different stages development so figures obtained tumor burden. also closely related immune control, humans. enhanced immunosuppressive drugs cortisone methotrexate, retarded immunoenhancing agents levamisole or BCG.