Molecular pathway network of EFNA1 in cancer and mesenchymal stem cells
作者： Shihori Tanabe , , Kazuhiko Aoyagi , Hiroshi Yokozaki , Hiroki Sasaki
DOI: 10.3934/CELLTISSUE.2018.2.58
关键词:
摘要: Abundant molecules are dynamically activated in cancer and stem cells. To investigate the role of ephrin A1 (EFNA1) cell signaling pathways, we analyzed gene expression molecular network EFNA1 mesenchymal cells (MSCs) diffuse-type gastric (GC). Diffuse-type GC has more mesenchymal-like feature malignant characteristics compared to intestinal-type GC. The were using several databases, including cBioPortal for Cancer Genomics, Kyoto Encyclopedia Genes Genomes (KEGG). was up-regulated MSCs. pathway includes cadherin 1 (CDH1), catenin beta (CTNNB1), ras-related C3 botulinum toxin substrate (rho family, small GTP binding protein Rac1) (RAC1), EPH receptor A5 (EPHA5), KRAS proto-oncogene, GTPase (KRAS). We summarized results revealed a model
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