Specificity of serum neutralizing antibodies induced by transient immune suppression of inapparent carrier ponies infected with a neutralization-resistant equine infectious anemia virus envelope strain.
作者： Laryssa Howe , Jodi K. Craigo , Charles J. Issel , Ronald C. Montelaro
关键词:
摘要: It has been previously reported that transient corticosteroid immune suppression of ponies experimentally infected with a highly neutralization resistant envelope variant equine infectious anemia virus (EIAV), designated EIAVΔPND, resulted in the appearance type-specific serum antibodies to infecting EIAVΔPND virus. The current study was designed determine if this induction neutralizing associated changes specificity determinants targeted by or caused nature defined surface gp90 V3 and V4 determinants. To address question, post-immune were mapped. results demonstrated sensitivity mapped specifically domains, individually combination. Thus, these data indicate development due an enhancement host antibody responses increase replication.
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