Recent advances in the chemistry of potassium channel openers

摘要: Among the large number of potassium channels so far described, ATP-sensitive K+ (K ATP channels) have recently attracted considerable interest since current studies revealed their essential role in diverse fundamental physiological processes. Such ATP-regulated been identified numerous cell types including endocrine cells, smooth muscle cardiac cells and central neurons. During last few years, amount chemical agents with channel opening properties has greatly expanded. These openers (PCOs) are expected to exert biological activity though activation K channels. PCOs display several potential clinical applications currently used treatment different cardiovascular disorders. However, development as new drugs importance will depend upon tissue selectivity affinity for a single subtype. This review presents recent progresses chemistry reports aspects governing