The effect of clopidogrel incombination with aspirin whengiven before coronary artery bypass grafting

摘要: Abstract Objectives This study was designed to evaluate the effect of preoperative clopidogrel on coronary artery bypass graft surgery (CABG) outcomes. Background Clopidogrel in combination with aspirin, given before percutaneous intervention, has become standard for stent thrombosis prevention. Some premedicated patients, however, are found have surgical disease angiography, and irreversible platelet inhibition becomes a concern upcoming CABG. Methods We prospectively studied 224 consecutive patients undergoing nonemergent first-time CABG, compared those exposure within seven days (n = 59) without 165). Results The groups were comparable age, gender, body surface area, hematocrit, prothrombin time prior myocardial infarction. group had higher 24-h mean chest tube output (1,224 ml vs. 840 ml, p 0.001), more transfusions red blood cells (2.51 U 1.74 U, 0.036), platelets (0.86 0.24 0.001) fresh frozen plasma (0.68 0.015). Moreover, reoperation bleeding 10-fold (6.8% 0.6%, 0.018). also less extubation 8 h (54.2% 75.8%, 0.002) trend towards hospital discharge five (33.9% 46.7%, 0.094). Conclusions aspirin CABG is associated postoperative morbidity. These findings raise regarding routine administration anticipated implantation.