摘要: Abstract : Catalytic antibodies are proteins that catalyze chemical reactions by binding to the transition state and lowering energy of activation. Transition analogs stable compounds mimic geometry electronic structure structure. These haptens conjugated used elicit desired immunoglobulins. have been accelerate hydrolysis ammonolysis reactions, cis-trans isomerizations, Diels-Alder alter product ratios for cyclization reactions.
datacite.org 参考文章(3)
K. Janda, D Schloeder, S. Benkovic, R. Lerner, Induction of an antibody that catalyzes the hydrolysis of an amide bond. Science. ,vol. 241, pp. 1188- 1191 ,(1988) , 10.1126/SCIENCE.3413482
Jim Na, K. N. Houk, Charles G. Shevlin, Kim D. Janda, Richard A. Lerner, The energetic advantage of 5-exo versus 6-endo epoxide openings: a preference overwhelmed by antibody catalysis Journal of the American Chemical Society. ,vol. 115, pp. 8453- 8454 ,(1993) , 10.1021/JA00071A067
S. J. Benkovic, A. D. Napper, R. A. Lerner, Catalysis of a stereospecific bimolecular amide synthesis by an antibody. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 85, pp. 5355- 5358 ,(1988) , 10.1073/PNAS.85.15.5355