Deficiencies in fat-soluble vitamins in long-term users of somatostatin analogue.

摘要: Aliment Pharmacol Ther 2010; 32: 1398–1404 Summary Background  Somatostatin analogues are administered to control hormone hypersecretion in acromegaly and carcinoid patients. can increase fat the stools, which lead loss of fat-soluble vitamins. The effect long-term somatostatin analogue use on vitamin levels remains unknown. Aim  To investigate prevalence deficiencies users. Methods  All patients using for ≥ 18 months visiting University Medical Center Groningen between December 2008 April 2009 were eligible. Vitamin vitamins blood, clinical vitamin-dependent laboratory parameters collected. Results  In all, 19 35 included. Twelve experienced steatorrhoea; two night blindness. Forty-two (78%) deficient one or more vitamins, 32% (n = 17) had multiple deficiencies. Deficiencies A, D, E, K1 E erythrocytes occurred 6%, 28%, 15%, 63% 58% Prevalence was similar both patient groups. Treatment duration did not influence levels. length intestinal resection age correlated negatively with A levels. Conclusions  Fat-soluble frequent during treatment. Therefore, should be monitored these