Shared transcription factors contribute to distinct cell fates.

摘要: Genome-wide transcription factor (TF) binding profiles differ dramatically between cell types. However, not much is known about the relationship cell-type-specific patterns and gene expression. A recent study demonstrated how same TFs can have functional roles when to largely non-overlapping genomic regions in hematopoietic progenitor mast cells. Cell-type specific of shared are therefore merely consequence opportunistic functionally irrelevant accessible chromatin, but instead potential make meaningful contributions cell-type transcriptional programs.