Cellular imaging and texture analysis distinguish differences in cellular dynamics in mouse brain tumors

摘要: Purpose The heterogeneous tumor cell population and dynamic microenvironment within a lead to regional variations in proliferation, migration, differentiation. In this work, MRI optical projection tomography were used examine compare the redistribution of cellular label two mouse glioma models. Methods GL261 4C8 cells labeled with iron oxide particles or fluorescent probe injected into brains syngeneic mice allowed develop ∼10-mm3 tumors. Texture analysis was quantitatively describe distribution patterns types. Results The seen remain predominantly core GL261 tumors, but become more randomly distributed throughout volume Histologically, tumors displayed invasive, aggressive phenotype, although mitotic similar. Conclusion The during growth is characteristic model. The map reflects than simple differences proliferation likely influenced by microenvironment. Magn Reson Med 71:1531–1541, 2014. © 2013 Wiley Periodicals, Inc.