Synapsins as mediators of BDNF- enhanced neurotransmitter release
作者： Jasmina N. Jovanovic , Andrew J. Czernik , Allen A. Fienberg , Paul Greengard , Talvinder S. Sihra
DOI: 10.1038/73888
关键词:
摘要: We examined enhancement of synaptic transmission by neurotrophins at the presynaptic level. In a synaptosomal preparation, brain-derived neurotrophic factor (BDNF) increased mitogen-activated protein (MAP) kinase-dependent synapsin I phosphorylation and acutely facilitated evoked glutamate release. PD98059, used to inhibit MAP kinase activity, markedly decreased concomitantly reduced neurotransmitter The stimulation release BDNF was strongly attenuated in mice lacking and/or II. These results indicate causal link via BDNF, TrkB receptors with downstream facilitation
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