DNA alkylation and neuro-oncogenesis by 3,3-dimethyl-1-phenyltriazene.
作者： H. K. Cooper , E. Hauenstein , G. F. Kolar , P. Kleihues
DOI: 10.1007/BF00685004
关键词:
摘要: The role of DNA alkylation by the neurooncogenic agent 3,3-dimethyl-1-phenyltriazene (DMPT) was investigated perinatally and in adult rats. Following a single subcutaneous injection of14C-DMPT (100 mg/kg) on 21st day gestation, concentration methylated purines similar both fetal liver brain whereas during postnatal growth this treatment resulted an increasingly preferential methylation DNA. In 30-day-old rats 7-methylguanine about 8 times higher DNA, suggesting that prenatal development are transplacentally proximate carcinogen produced maternal organs. Multiple doses (50 to led accumulation O6-methylguanine cerebral This supports hypothesis deficient repair excision capacity central nervous system is significant factor organ-specific carcinogenicity DMPT related carcinogens.
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sci-hub.se 参考文章(24)
R. Preussmann, S. Ivankovic, C. Landsch�tz, J. Gimmy, E. Flohr, U. Griesbach, [Carcinogenic activity of 13 aryldialkyl triazenes in BD-rats (author's transl)]. Zeitschrift für Krebsforschung. ,vol. 81, pp. 285- 310 ,(1974) , 10.1007/BF00305031
G P Margison, P Kleihues, Chemical carcinogenesis in the nervous system. Preferential accumulation of O6-methylguanine in rat brain deoxyribonucleic acid during repetitive administration of N-methyl-N-nitrosourea Biochemical Journal. ,vol. 148, pp. 521- 525 ,(1975) , 10.1042/BJ1480521
D. Stavrou, Beitrag zur Morphologie und Enzymhistochemie experimenteller Tumoren des Zentralnervensystems der Ratte Acta Neuropathologica. ,vol. 15, pp. 231- 239 ,(1970) , 10.1007/BF00686769
Lois L. Gerchman, David B. Ludlum, The properties of O6-methylguanine in templates for RNA polymerase Biochimica et Biophysica Acta. ,vol. 308, pp. 310- 316 ,(1973) , 10.1016/0005-2787(73)90160-3
Brief Communication: Carcinogenicity of N-Methyl-N-nitrosourea: Possible Role of Excision Repair of O6-Methylguanine From DNA Journal of the National Cancer Institute. ,vol. 53, pp. 1839- 1841 ,(1974) , 10.1093/JNCI/53.6.1839
R. Preussmann, H. Druckrey, S. Ivankovic, A. v. Hodenberg, CHEMICAL STRUCTURE AND CARCINOGENICITY OF ALIPHATIC HYDRAZO, AZO, AND AZOXY COMPOUNDS AND OF TRIAZENES, POTENTIAL IN VIVO ALKYLATING AGENTS Annals of the New York Academy of Sciences. ,vol. 163, pp. 697- 716 ,(1969) , 10.1111/J.1749-6632.1969.TB24888.X
R. Goth, M. F. Rajewsky, Persistence of O6-ethylguanine in rat-brain DNA: correlation with nervous system-specific carcinogenesis by ethylnitrosourea. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 71, pp. 639- 643 ,(1974) , 10.1073/PNAS.71.3.639
B. Singer, Nucleic acid alkylation, mutation and carcinogenesis: is there a relationship? Trends in Biochemical Sciences. ,vol. 2, pp. 180- 183 ,(1977) , 10.1016/0968-0004(77)90073-1
H. Druckrey, R. Preussmann, S. Ivankovic, D. Schm�hl, J. Afkham, G. Blum, H. D. Mennel, M. M�ller, P. Petropoulos, H. Schneider, Organotrope carcinogene Wirkungen bei 65 verschiedenen N-Nitroso-Verbindungen an BD-Ratten Zeitschrift für Krebsforschung. ,vol. 69, pp. 103- 201 ,(1967) , 10.1007/BF00524152
H. Druckrey, S. Ivankovic, R. Preussmann, Neurotrope carcinogene Wirkung von Phenyl-dimethyl-triazen an Ratten Naturwissenschaften. ,vol. 54, pp. 171- 171 ,(1967) , 10.1007/BF00590849