Chapter 58 – Are Vaccinations for Prostate Cancer Realistic?

摘要: Tumor cells possess a virtually unlimited number of antigens, the majority which have not been identified. Vaccination against infectious agents occur prior to exposure in order prevent disease, whereas immune system has theoretically already exposed tumor antigens case cancer vaccine and, therefore, may be “tolerant” that antigen. The vaccines focuses on stimulating different arm response, cell-mediated immunity, compared desired humoral response agents. interest therapy for increased tremendously over past decade. goal immunology is understand malignant and able use this knowledge create novel therapeutic strategies. need effective adjuvant treatment options prostate seems obvious. Dramatic advances available molecular techniques increasing understanding antigen presentation recognition led much renewed possibility vaccine. escape from surveillance remains largely unexplained, despite tremendous identifying vaccines, few found are truly unique tumors. exact role immunotherapy will management yet defined remain way near future given time required complete phase III trials disease.