Circulating Survivin Levels in Obstructive Sleep Apnoea.

摘要: INTRODUCTION Obstructive sleep apnoea (OSA) is characterised by a low-grade systemic and airway inflammation; however, the regulatory mechanisms of inflammation are poorly explored. Survivin (Birc5) an anti-apoptotic protein which inhibits Type 1 this molecule has not been investigated in OSA. METHODS Forty-five patients with OSA 31 non-OSA control subjects were involved. Venous blood was collected for plasma survivin measurements before after diagnostic overnight polysomnography. Plasma levels compared between two groups correlated to severity comorbidities. RESULTS lower evening (27.6 ± 89.9 vs. 108.3 ± 161.2 pg/ml, p   0.05). Low concentrations associated high BMI (r = - 0.35), CRP (r = - 0.31), low HDL cholesterol (r = 0.24) triglyceride (r = - 0.24, all p < 0.05). CONCLUSION reduced OSA, relate disease severity, levels. This suggests impaired immunoregulation disorder needs be studied further detail.