Reduced local segregation of single‐subject gray matter networks in adult PTSD
作者： Running Niu , Du Lei , Fuqin Chen , Ying Chen , Xueling Suo
DOI: 10.1002/HBM.24330
关键词:
摘要: To psychoradiologically investigate the topological organization of single-subject gray matter networks in patients with PTSD. Eighty-nine adult PTSD and 88 trauma-exposed controls (TEC) underwent a structural T1 magnetic resonance imaging scan. The brain were constructed based on similarity 90 regions. area under curve (AUC) each network metric was calculated both global nodal properties measured graph theory analysis. We used nonparametric permutation tests to identify group differences metrics. Relationships between measures clinical symptom severity analyzed group. Compared TEC, characterized by decreased clustering coefficient (Cp ) (p = .04) local efficiency (Eloc (p = .04). Locally, exhibited altered centrality involving medial superior frontal (mSFG), inferior orbital (iOFG), parietal (SPG), middle (MFG), angular, para-hippocampal gyri (p < .05, corrected). A negative correlation segregation functional found but not TEC Analyses indicate more randomly organized reduced its relation increased an inverse changes. present psychoradiological findings may reflect compensatory increase following loss networks.
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