Next-generation clinical trials: Novel strategies to address the challenge of tumor molecular heterogeneity.

作者: Daniel V.T. Catenacci

DOI: 10.1016/J.MOLONC.2014.09.011

关键词:

摘要: … Finally intra-patient heterogeneity through time may be addressed by serial biomarker assessment at the time of tumor progression. This report discusses various ‘next-generation’ …

参考文章(148)
Mark Pegram, Dennis Slamon, Biological rationale for HER2/neu (c-erbB2) as a target for monoclonal antibody therapy. Seminars in Oncology. ,vol. 27, pp. 13- 19 ,(2000)
Arne Warth, Thomas Muley, Esther Herpel, Michael Meister, Felix J F Herth, Peter Schirmacher, Wilko Weichert, Hans Hoffmann, Philipp A Schnabel, Large-scale comparative analyses of immunomarkers for diagnostic subtyping of non-small-cell lung cancer biopsies. Histopathology. ,vol. 61, pp. 1017- 1025 ,(2012) , 10.1111/J.1365-2559.2012.04308.X
RAS mutations in colorectal cancer. The New England Journal of Medicine. ,vol. 369, pp. 2159- 2160 ,(2013) , 10.1056/NEJMC1312697
Christoph Lengauer, Luis A. Diaz, Saurabh Saha, Cancer drug discovery through collaboration. Nature Reviews Drug Discovery. ,vol. 4, pp. 375- 380 ,(2005) , 10.1038/NRD1722
Daniel V.T. Catenacci, Andrea L. Amico, Sarah M. Nielsen, Daniel M. Geynisman, Brittany Rambo, George B. Carey, Cassandra Gulden, Jim Fackenthal, Robert D. Marsh, Hedy L. Kindler, Olufunmilayo I. Olopade, Tumor genome analysis includes germline genome: Are we ready for surprises? International Journal of Cancer. ,vol. 136, pp. 1559- 1567 ,(2015) , 10.1002/IJC.29128
Ruiyang Yan, Andrew Hallam, Peter G. Stockley, Joan Boyes, Oncogene dependency and the potential of targeted RNAi-based anti-cancer therapy. Biochemical Journal. ,vol. 461, pp. 1- 13 ,(2014) , 10.1042/BJ20140173
Afshin Dowlati, Scot C. Remick, Lili Liu, James K. V. Willson, Sosamma J. Berger, Timothy P. Spiro, Stanton L. Gerson, Nathan A. Berger, John Haaga, Sequential tumor biopsies in early phase clinical trials of anticancer agents for pharmacodynamic evaluation. Clinical Cancer Research. ,vol. 7, pp. 2971- 2976 ,(2001)
S. Bellou, G. Pentheroudakis, C. Murphy, T. Fotsis, Anti-angiogenesis in cancer therapy: Hercules and hydra Cancer Letters. ,vol. 338, pp. 219- 228 ,(2013) , 10.1016/J.CANLET.2013.05.015
Daniel J. Sargent, Barbara A. Conley, Carmen Allegra, Laurence Collette, Clinical Trial Designs for Predictive Marker Validation in Cancer Treatment Trials Journal of Clinical Oncology. ,vol. 23, pp. 2020- 2027 ,(2005) , 10.1200/JCO.2005.01.112