Differential modulation of nociceptive neural responses in medial and lateral pain pathways by peripheral electrical stimulation: a multichannel recording study.

摘要: It is well accepted that peripheral electrical stimulation (PES) can produce an analgesic effect in patients with acute and chronic pain. However, the neural basis underlying stimulation-induced analgesia remains unclear. In present study, we examined pain-related activity modified by rats. The frequency of pulses applied to needle electrodes hindlimb was 2 Hz alternating 100 Hz, 0.6 ms pulse width for 0.2 Hz. intensity increased stepwise from 1 3 mA each 1-mA step lasting 10 min. nociceptive behavioral responses were immediately after termination stimulation. Using a multiple-channel recording technique, simultaneously recorded many single neurons located primary somatosensory anterior cingulate cortex (ACC), as ventral posterior medial dorsal thalamus behaving Our results showed significantly reduced ventroposterior cortex, indicating inhibition processing. contrast, produced significant increase mediodorsal while less decrease reflecting complicated associated combined antinociceptive activation suppression. These support idea ultimately alter pain perception specifically inhibiting transmission sensory pathway mobilizing action affective pathway, thus relief.