Photodynamic Diagnosis and Therapy for Brain Malignancies from the Bench to Clinical Application

摘要: Glioblastomas are the third most common cause of cancer death in patients between 15 and 35 years. Photodynamic diagnosis (PDD), fluorescence guided tumour resection (FGR) photodynamic therapy (PDT) is undergoing intensive clinical investigations as adjuvant treatment for malignant brain tumours. Besides many reports on phase I/II trials PDT tumours, there only few controlled trials. Variations protocols make evaluation scientifically difficult; however, a clear trend towards prolonging median survival after one single photo dynamic compared to standard therapeutic regiments. According met-analysis primary glioblastoma multi-forme WHO IV was 22 months recurrent GBM 9 conventional which 3 months, respectively. Fluorescence-guided demonstrated significant greater reduction burden. The combination PDD/FGR intra operative (“to see treat”) offers an exciting approach supported by observational studies with combined total > 1,000 GBMs. highly selective, safe, significantly improved good quality delayed relapse (p < 0.001). following chapter provides overview current data well photosensitisers, technical developments indications application neurosurgery.