Cytotoxic triterpenes from the aerial roots of Ficus microcarpa.
作者： Yi-Ming Chiang , Jang-Yang Chang , Ching-Chuan Kuo , Chi-Yen Chang , Yueh-Hsiung Kuo
DOI: 10.1016/J.PHYTOCHEM.2004.12.026
关键词:
摘要: Six triterpenes, 3beta-acetoxy-12,19-dioxo-13(18)-oleanene (1), 3beta-acetoxy-19(29)-taraxasten-20alpha-ol (2), 3beta-acetoxy-21alpha,22alpha-epoxytaraxastan-20alpha-ol (3), 3,22-dioxo-20-taraxastene (4), 3beta-acetoxy-11alpha,12alpha-epoxy-16-oxo-14-taraxerene (5), 3beta-acetoxy-25-methoxylanosta-8,23-diene (6) along with nine known 3beta-acetoxy-11alpha,12alpha-epoxy-14-taraxerene (7), 3beta-acetoxy-25-hydroxylanosta-8,23-diene (8), oleanonic acid (9), acetylbetulinic (10), betulonic (11), acetylursolic (12), ursonic (13), ursolic (14), and 3-oxofriedelan-28-oic (15) were isolated from the aerial roots of Ficus microcarpa, their structures elucidated by spectroscopic methods. The in vitro cytotoxic efficacy these triterpenes was investigated using three human cancer cell lines, namely, HONE-1 nasopharyngeal carcinoma, KB oral epidermoid HT29 colorectal carcinoma cells. Compound 8 pentacyclic 9-15 possessing a carboxylic functionality at C-28 showed significant activities against aforementioned lines gave IC50 values range 4.0-9.4 microM.
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