Effects of guanidino modified aminoglycosides on mammalian membranes studied using a quartz crystal microbalance.
作者： Torsten John , Zhi Xiang Voo , Clemens Kubeil , Bernd Abel , Bim Graham
DOI: 10.1039/C7MD00054E
关键词:
摘要: The increase in bacterial and viral resistance to current therapeutics has led intensive research for new antibacterial antiviral agents. Among these, aminoglycosides their guanidino derivatives are potent candidates targeting specific RNA sequences. It is necessary that these substances can pass across mammalian membranes order reach intracellular targets. This study investigated the effects of kanamycin A neomycin B on mimetic using a quartz crystal microbalance with dissipation monitoring (QCM-D). Lipid bilayers as membrane models were deposited onto gold coated crystals added afterwards. Notably, exhibited an initial stiffening layer indicating quick insertion planar groups into membrane. also reached maximum binding at lower concentrations than native compounds. Therefore, modified promising agents development antimicrobial treatments.
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sci-hub.se 参考文章(63)
, Combating antimicrobial resistance: policy recommendations to save lives. Clinical Infectious Diseases. ,vol. 52, ,(2011) , 10.1093/CID/CIR153
T.P. Zimmerman, W.B. Mahony, K.L. Prus, 3'-azido-3'-deoxythymidine. An unusual nucleoside analogue that permeates the membrane of human erythrocytes and lymphocytes by nonfacilitated diffusion. Journal of Biological Chemistry. ,vol. 262, pp. 5748- 5754 ,(1987) , 10.1016/S0021-9258(18)45638-4
Sylvie Garneau-Tsodikova, Kristin J. Labby, Mechanisms of resistance to aminoglycoside antibiotics: overview and perspectives MedChemComm. ,vol. 7, pp. 11- 27 ,(2016) , 10.1039/C5MD00344J
Felix Freire, Igor Cuesta, Francisco Corzana, Julia Revuelta, Carlos González, Milos Hricovini, Agatha Bastida, Jesús Jiménez-Barbero, Juan Luis Asensio, A simple NMR analysis of the protonation equilibrium that accompanies aminoglycoside recognition: Dramatic alterations in the neomycin-B protonation state upon binding to a 23-mer RNA aptamer Chemical Communications. ,vol. 2, pp. 174- 176 ,(2007) , 10.1039/B611597G
Richard J. Fair, Mary E. Hensler, Wdee Thienphrapa, Quang N. Dam, Victor Nizet, Yitzhak Tor, Selectively guanidinylated aminoglycosides as antibiotics. ChemMedChem. ,vol. 7, pp. 1237- 1244 ,(2012) , 10.1002/CMDC.201200150
Yanet Fuentes-Martínez, Carolina Godoy-Alcántar, Felipe Medrano, Alexander Dikiy, Anatoly K. Yatsimirsky, Protonation of kanamycin A: detailing of thermodynamics and protonation sites assignment. Bioorganic Chemistry. ,vol. 38, pp. 173- 180 ,(2010) , 10.1016/J.BIOORG.2010.04.003
Jan Tkac, Jason J. Davis, An optimised electrode pre-treatment for SAM formation on polycrystalline gold Journal of Electroanalytical Chemistry. ,vol. 621, pp. 117- 120 ,(2008) , 10.1016/J.JELECHEM.2008.04.010
Nam-Joon Cho, Kay K. Kanazawa, Jeffrey S. Glenn, Curtis W. Frank, Employing two different quartz crystal microbalance models to study changes in viscoelastic behavior upon transformation of lipid vesicles to a bilayer on a gold surface Analytical Chemistry. ,vol. 79, pp. 7027- 7035 ,(2007) , 10.1021/AC0709504
Joachim K. Seydel, Eugene A. Coats, Hans Peter Cordes, Michael Wiese, Drug Membrane Interaction and the Importance for Drug Transport, Distribution, Accumulation, Efficacy and Resistance Archiv der Pharmazie. ,vol. 327, pp. 601- 610 ,(1994) , 10.1002/ARDP.19943271002
Jonathan S. Ellis, Michael Thompson, Viscoelastic modeling with interfacial slip of a protein monolayer electrode-adsorbed on an acoustic wave biosensor. Langmuir. ,vol. 26, pp. 11558- 11567 ,(2010) , 10.1021/LA100798C