The burden of herpes zoster and postherpetic neuralgia in the United States.

摘要: Herpes zoster (shingles), a painful and disabling disease, affects an estimated 1 million individuals in the United States annually results significant morbidity, lost productivity, diminished quality of life. constitutes reactivation varicella-zoster virus (VZV), same that causes chickenpox. After resolution chickenpox, VZV remains dormant dorsal root ganglia. Varicella-zoster-specific cell-mediated immunity wanes naturally with advancing age or earlier setting altered immune status, which can result as herpes zoster. The pain associated rash caused by is often described burning, stabbing, itching, aching. Postherpetic neuralgia, most common complication zoster, occurs after has resolved, affecting up to third patients. especially elderly. both more severe among older adults. In acute postherpetic primary cause morbidity.