Modulation of the helical properties of DNA: next-to-nearest neighbour effects and beyond.
作者： Alexandra Balaceanu , Diana Buitrago , Jürgen Walther , Adam Hospital , Pablo D Dans
DOI: 10.1093/NAR/GKZ255
关键词:
摘要: We used extensive molecular dynamics simulations to study the structural and dynamic properties of central d(TpA) step in highly polymorphic d(CpTpApG) tetranucleotide. Contrary assumption dinucleotide-model its nearest neighbours (tetranucleotide-model), change quite significantly dependent on next-to-nearest (hexanucleotide) sequence context a few cases are modulated by even remote (beyond from TpA). Our results highlight existence previously undescribed dynamical mechanisms for transmission information into DNA demonstrate certain sequences with special physical that can impact global structure dynamics.
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