Coronary Artery Calcification and Myocardial Perfusion in Asymptomatic Adults: The MESA (Multi-Ethnic Study of Atherosclerosis)

摘要: The identification of subclinical coronary heart disease (CHD) before the occurrence critical events is important for prevention. Use multiple risk factors to assess CHD has limited predictive value in a given individual. Further noninvasive methods, such as artery calcium scanning, have been developed detect atherosclerosis. Both pathological (1–3) and angiographic (4–6) data documented that burden closely correlates with extent severity total atherosclerosis. Impairment vascular reactivity caused by atherosclerosis can be detected using imaging myocardial blood flow (MBF) MBF response vasoactive stimuli. Myocardial perfusion during exercise or vasodilator-induced vasodilation was found valuable predicting future events, even patients known at relatively low (7). Current knowledge about calcification (CAC), structural marker, perfusion, functional parameter, suggest they could complementary tests, whose relation may nevertheless vary age, gender, profile, clinical history CHD. In settings, prevalence stress-induced ischemia seen increase CAC among suspected (8,9). Vasoreactivity impaired early process, absence ischemic symptoms (10–12). Whether an association between exists general population asymptomatic subjects remains largely unknown. Furthermore, relationship free-living individuals without CHD, if any, differ younger versus older people men women. To address these questions, this study assessed cross-sectional rest hyperemia, middle-age adults who participated large population-based study. We hypothesized inversely associated CAC.