Comparative properties of four galactosyl lipids as antigens in liposomes.
作者： Carl R Alving , John W Fowble , Kenneth C Joseph
DOI: 10.1016/0019-2791(74)90118-9
关键词:
摘要: Abstract Two sphingosyl galactolipids, galactocerebroside and mixed gangliosides, two glyceryl mono digalactosyl diglycerides, were compared for immunological activity in liposomal model membranes. The liposomes prepared with one of several synthetic lecithins or beef sphingomyelin. Specific complement-dependent glucose release as was found all cases, although high titer antiserum not obtained against monogalactosyl diglyceride. With galactocerebroside, the degree inversely related to phospholipid fatty acid chain length. relative efficiencies these substances terms antigenic expression and/or immunogenicity order: ganglioside > diglyceride Reciprocal serological cross-reactivity observed between on hand diglycerides other. Cross-reactivity groups occured four out six possible combinations studied. Anti-digalactosyl only anti-serum an apparent specificity it did cross-react either cerebroside ganglioside. influenced by length, antigen concentration antibody immunizing antigen.
elsevier.com
sci-hub.se 参考文章(16)
Maurice M. Rapport, Liselotte Graf, Immunochemical reactions of lipids. Progress in allergy. ,vol. 13, pp. 273- 331 ,(1969) , 10.1159/000385923
AKIRA MAKITA, CHIYUKI SUZUKI, ZENSAKU YOSIZAWA, Chemical and immunological characterization of the Forssman hapten isolated from equine organs Journal of Biochemistry. ,vol. 60, pp. 502- 513 ,(1966) , 10.1093/OXFORDJOURNALS.JBCHEM.A128468
Bader Siddiqui, Sen-Itiroh Hakomori, A Revised Structure for the Forssman Glycolipid Hapten Journal of Biological Chemistry. ,vol. 246, pp. 5766- 5769 ,(1971) , 10.1016/S0021-9258(18)61871-X
Eberhard G. Trams, Carl J. Lauter, On the isolation and characterization of gangliosides Biochimica et Biophysica Acta. ,vol. 60, pp. 350- 358 ,(1962) , 10.1016/0006-3002(62)90410-9
Carl R. Alving, Stephen C. Kinsky, James A. Haxby, Constance B. Kinsky, Antibody binding and complement fixation by a liposomal model membrane. Biochemistry. ,vol. 8, pp. 1582- 1587 ,(1969) , 10.1021/BI00832A038
Theresa A. Pascal, A. Saifer, IMMUNOCHEMICAL STUDIES OF ISOLATED HUMAN BRAIN GANGLIOSIDE COMPONENTS Journal of Neurochemistry. ,vol. 16, pp. 301- 307 ,(1969) , 10.1111/J.1471-4159.1969.TB10368.X
Stephen C. Kinsky, James A. Haxby, David A. Zopf, Carl R. Alving, Constance B. Kinsky, Complement-dependent damage to liposomes prepared from pure lipids and Forssman hapten. Biochemistry. ,vol. 8, pp. 4149- 4158 ,(1969) , 10.1021/BI00838A036
Stephen Kinsky, James Haxby, David Zopf, Carl Alving, Constance Kinsky, Corrections - Complement-Dependent Damage to Liposomes Prepared from Pure Lipids and Forssman Hapten Biochemistry. ,vol. 9, pp. 1048- 1048 ,(1970) , 10.1021/BI00806A602
S. C. Kinsky, K. Inoue, T. Kataoka, Comparative responses of liposomes prepared with different ceramide antigens to antibody and complement Biochemistry. ,vol. 10, pp. 2574- 2581 ,(1971) , 10.1021/BI00789A025
Lars Svennerholm, The chemical structure of normal human brain and Tay-Sachs gangliosides Biochemical and Biophysical Research Communications. ,vol. 9, pp. 436- 441 ,(1962) , 10.1016/0006-291X(62)90030-X