Activation of fibroblast growth factor receptor 3 and oncogene-induced senescence in skin tumours
作者： Y. Hida , Y. Kubo , S. Arase
DOI: 10.1111/J.1365-2133.2009.09068.X
关键词:
摘要: Summary Background The activation of oncogenes is an important step in tumorigenesis, and recently, oncogene-induced senescence (OIS) was proposed as a critical barrier against malignant transformation normal primary cells. Objectives aim this study to examine the fibroblast growth factor receptor 3 (FGFR3) oncogene product OIS human skin tumours. Methods We investigated FGFR3 by mutation immunohistochemical analysis tumours, including seborrhoeic keratosis, actinic keratosis (AK), Bowen’s disease (BD), basal cell carcinoma (BCC) squamous (SCC). Results Activated point mutations were identified four 22 cases (18%) but no detected other tumours. Twenty-seven 31 (87%) showed moderately strongly positive expression protein, almost all tumours negative. On hand, keratoses negative immunoreactivity for antiphoshohistone H2AX (γ-H2AX) marker OIS, 17 (77%) AK positive. Immunoreactivity γ-H2AX significantly greater than BD, BCC SCC. Conclusions might be common feature tumorigenesis although does not induce typical oncogenic signal keratinocytes. In addition, due some signals rather involved early carcinogenesis related chronic ultraviolet radiation exposure.
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