Radiotherapy as a local treatment option for heterotopic ossifications in patients with spinal cord injury.

摘要: Objective: Heterotopic ossifications (HO) occur in about 20% of patients with spinal cord injury and may seriously compromise the rehabilitation process. The aim present study was to ascertain whether radiotherapy (RT) administered early course disease prevents manifestation HO patients, whose have been resected, recurrence can be avoided. Methods: Thirty-six (46 joints) were irradiated; 33 evaluable. Mean follow up 23.6 months. In 27 RT performed as primary treatment inflammatory phase soft tissue swelling that precedes manifest HO. Eleven treated after resection HO, while two had postoperative different joints. dose 10 Gy fractions 2–2.5 Gy 25 patients. Four total doses between 7.5 20 Gy. Seven received single irradiation 8 Gy. 8 MV photons simulation on basis CT scans. Results: The mean duration Thirty 36 irradiated showed no progression three reossifications therapy caused a moderate decrease joint mobility. No relevant adverse effects observed. Conclusion: These results suggest is safe effective local option for Spinal Cord (2000) 38, 33–36.