Signal transduction pathways in cancer development and as targets for cancer prevention.

摘要: Publisher Summary This chapter summarizes work in signal transduction pathways involved neoplastic cell transformation and carcinogenesis, presents strong evidence for these as effective targets chemopreventive agents. The study of the molecular mechanisms cancer development action anticancer agents prevention is discussed this chapter. It address fundamental questions concerning response animal and/or human cells to carcinogens tumor promoters, such UV light, arsenic, TPA, growth factors established a series necessary models or systems, over-agar assay , gene knockout mice, transcription factor/luciferase promoter stably transfected transgenic well knockdown (siRNA) dominant-negative mutant lines. These have been extensively utilized examine promoter-induced their role transformation. discusses networks induced by UVA, UVB UVC, describes critical roles MAP kinases at all three unique wavelengths UV-induced pathways. Some most interesting documented are resveratrol components tea, EGCG, theaflavins, caffeine. Other potentially dietary compounds include inositol hexaphosphate, PEITC, ginger, CAPE. A continuing emphasis on obtaining rigorous research data analysis those regarding other food vital determine basis long-term effectiveness safety Large-scale biology studies needed bioavailability, toxicity, target, pathways, side effects factors. Clinical trials based clear mechanistic also assess population.