Transformation of low grade glioma and correlation with outcome: an NCCTG database analysis

摘要: Glioblastomas (GBM) may originate de novo (primary), or following transformation from a lower grade glioma (secondary), and it has been postulated that these tumors have different biological behaviors. We performed correlative analysis involving 204 patients with treated prospectively on NCCTG clinical trials. Central pathology review of tumor tissues taken at the time initial diagnosis recurrence were in all patients. Tumors progressed low (WHO 2) to high (grade 3–4) 45% oligodendroglioma patients, 70% oligoastrocytoma, 74% astrocytoma (P = 0.031). Median overall survival (OS) varied by histology: oligodendroglioma, 8.8 years; (95% CI 5.7–10.2); 4.4 years 3.5–5.6); 2 3.1 (astrocytoma 2–4, 2.1 years) 1.7–2.5, P < 0.001). Mean (TTR) also between GBM, those secondary remained non-GBM (1.1 ± 1.1 vs. 2.9 1.8 4.0 years, respectively, OS three categories (0.7 95% CI: 0.5–1.1 0.6 0.5–1.0 1.4 1.1–2.0, respectively) At relapse, higher is frequent pure mixed astrocytomas, but observed less than half oligodendroglioma. From recurrence, was not significantly for primary versus thus be reasonable include GBM therapeutic trials recurrent disease.