The association between nonalcoholic fatty liver disease and esophageal, stomach, or colorectal cancer: National population-based cohort study.

摘要: We investigated the association between nonalcoholic fatty liver disease (NAFLD) and gastrointestinal tract cancer in general population. Retrospective data on individuals aged ≥20 years who received healthcare checkups from January 1, 2009 to December 31, were analyzed using National Health Insurance Database Korea. NAFLD was defined based index (FLI ≥60). The primary outcome newly diagnosed esophageal, stomach, or colorectal ICD-10 codes during follow-up until 31 2017. Cox regression analysis used estimate hazard ratios (HRs) 95% confidence intervals (95% CIs). Among 8,120,674 subjects, 936,159 adults (11.5%) identified as having NAFLD. Their mean age 46.7 ± 14.1 years, 52.1% male. During period (7.2 years), 3,792 57,292 stomach 68,769 cases identified. FLI ≥60 significantly associated with development of esophageal (HR 2.10, CI 1.88-2.35), 1.18, 1.14-1.22), colon (HR, 1.23, 1.19-1.26) after multivariable adjustment. Compared subjects without NAFLD, all-cause mortality patients 1.46, 1.28-1.67), 1.26, 1.18-1.34), 1.16, 1.10-1.22) increased a good predictive indicator for GI malignancy Subjects are needed active surveillance cancers.