Early Clinical Experience with Farnesyl Protein Transferase Inhibitors
作者： Amita Patnaik , Eric K. Rowinsky
DOI: 10.1007/978-1-59259-013-1_15
关键词:
摘要: The ability to target anticancer therapies specific molecular components of the signal transduction cascade involved in malignant transformation represents a major therapeutic advance development cytostatic antineoplastic agents. Inhibitors Ras farnesylation are examples such molecularly targeted and culmination rational drug design dedicated high-throughput screening natural products libraries. Protein farnesyltransferase (FTase) inhibitors (FTIs) now entering early phase clinical investigations alone combination, with encouraging preliminary safety pharmacologic data.
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