New strategies for the treatment of infections associated with prosthetic joints.

摘要: Treatment of infections associated with orthopedic devices usually requires appropriate surgical intervention combined a prolonged course antimicrobial therapy. The choice optimal management depends on duration and pathogenesis infection, stability the implant, susceptibility pathogen condition soft tissue. role rifampin in combination quinolones, minocycline, co-trimoxazole or fusidic acid treatment staphylococcal is outlined this review. Increasing resistance use alternative agents, such as quinupristin-dalfopristin, linezolid daptomycin, but results clinical trials are limited. Finally, agents potential for prophylaxis device-associated infections, novel rifamycin derivatives, compounds acting bacterial quorum-sensing mechanisms presented