Utilization Trends of Tumor Necrosis Factor Inhibitors Among Patients with Rheumatoid Arthritis in a United States Observational Cohort Study

摘要: Objective. Studies have suggested that early institution of tumor necrosis factor (TNF) inhibitors improves functional status and slows radiographic progression among patients with rheumatoid arthritis (RA). To determine whether these findings altered practice patterns, we used the Consortium Rheumatology Researchers North America (CORRONA) registry to assess pattern TNF inhibitor utilization in US over time. Methods. Demographics disease activity data were collected for RA. The trend use during 2002–06 was evaluated prospectively using linear logistic regression models. Results. Of 11,397 RA, 66% 34% had established RA (disease duration < 3 yrs), respectively. majority female Caucasian. Despite comparable levels activity, more taking than those (40% vs 25%; p 0.0001). (70%) also receiving modifying antirheumatic drugs. increased at a rate 2.8% per year 1.2% mean Clinical Disease Activity Index start decreased −0.233 quarter (p = 0.006), while Score −0.04 0.022). Conclusion. Utilization this multicenter, observational cohort is increasing both although it prominent level which initiated time