Role of Physical Exercise for Improving Posttraumatic Nerve Regeneration

摘要: Despite the great regenerative ability of peripheral nervous system (PNS), traumatic nerve damage often causes severe chronic disability. Rehabilitation following PNS trauma usually employs therapeutic exercise in an attempt to reanimate target organs and stimulate functional recovery. Over past years, important neurobiological determinants regeneration successful end-organ reinnervation were unveiled. Such knowledge provides cues for designing novel strategies treating rehabilitating damage. Physical exercise, by means treadmill or wheel running, is neuroprotective neuroregenerative. Research conducted on rodents demonstrates that endurance modulates several cellular molecular responses injury doing so it stimulates recovery experimental injury. Treadmill running increases number regenerating neurons, rate axonal growth, extent muscle Furthermore, has increase release neurotrophins growth factors spinal cord, injured nerve, reinnervating muscles. also seems prevent development neuropathic pain allodynia as a result In addition, physical even if performed short period time, exerts positive conditioning effects neuroregeneration capacity, improving acute response insults. Some these can be obtained with passive manual stimulation. humans, however, evidence demonstrating effect at best poor.