The Protein Kinase PKR is Critical for LPS-induced iNOS Production, but Dispensable for Inflammasome Activation in Macrophages

作者: Yuan He , Luigi Franchi , Gabriel Núñez

DOI: 10.1002/EJI.201243187

关键词:

摘要: … PKR, we found that PKR is important for the induction of the inducible nitric oxide synthase (iNOS). However, PKR … extend previous findings that PKR plays a role in LPS-induced iNOS …

参考文章(22)
Christian Bogdan, Nitric oxide and the immune response Nature Immunology. ,vol. 2, pp. 907- 916 ,(2001) , 10.1038/NI1001-907
Y. L. Yang, L. F. Reis, J. Pavlovic, A. Aguzzi, R. Schäfer, A. Kumar, B. R. Williams, M. Aguet, C. Weissmann, Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. The EMBO Journal. ,vol. 14, pp. 6095- 6106 ,(1995) , 10.1002/J.1460-2075.1995.TB00300.X
Luigi Franchi, Raul Muñoz-Planillo, Gabriel Núñez, Sensing and reacting to microbes through the inflammasomes Nature Immunology. ,vol. 13, pp. 325- 332 ,(2012) , 10.1038/NI.2231
Thirumala-Devi Kanneganti, Nesrin Özören, Mathilde Body-Malapel, Amal Amer, Jong-Hwan Park, Luigi Franchi, Joel Whitfield, Winfried Barchet, Marco Colonna, Peter Vandenabeele, John Bertin, Anthony Coyle, Ethan P. Grant, Shizuo Akira, Gabriel Núñez, Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3 Nature. ,vol. 440, pp. 233- 236 ,(2006) , 10.1038/NATURE04517
Li-Chung Hsu, Jin Mo Park, Kezhong Zhang, Jun-Li Luo, Shin Maeda, Randal J. Kaufman, Lars Eckmann, Donald G. Guiney, Michael Karin, The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4 Nature. ,vol. 428, pp. 341- 345 ,(2004) , 10.1038/NATURE02405
Vijay A K Rathinam, Sivapriya Kailasan Vanaja, Katherine A Fitzgerald, Regulation of inflammasome signaling Nature Immunology. ,vol. 13, pp. 333- 342 ,(2012) , 10.1038/NI.2237
Dionissios Baltzis, Suiyang Li, Antonis E. Koromilas, Functional Characterization of pkr Gene Products Expressed in Cells from Mice with a Targeted Deletion of the N terminus or C terminus Domain of PKR Journal of Biological Chemistry. ,vol. 277, pp. 38364- 38372 ,(2002) , 10.1074/JBC.M203564200