B7-DC variants
作者： Lieping Chen
DOI:
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摘要: Compositions and methods for costimulating T cells (i.e., increasing antigen-specific proliferation of cells, enhancing cytokine production by stimulating differentiation ad effector functions and/or promoting cell survival) are provided. Suitable compositions include variant B7-DC polypeptides, fragments fusion proteins thereof. Variant polypeptides have reduced binding affinity the inhibitory PD-I ligand substantially retain ability to costiniulate cells. Methods using stimulate immune responses in subjects need thereof
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