c-Met, CREB1 and EGFR are involved in miR-493-5p inhibition of EMT via AKT/GSK-3β/Snail signaling in prostate cancer.
作者： Song Wang , Xiao Wang , Jiangfeng Li , Shuai Meng , Zhen Liang
DOI: 10.18632/ONCOTARGET.19398
关键词:
摘要: miR-493-5p downregulation has emerged as a critical player in cancer progression yet, the underlying mechanisms of expression pattern and its function prostate remains to be elucidated. Here, we illustrate that is frequently downregulated cancer, at least partially due altered DNA methylation. functions tumor suppressor cells. c-Met, CREB1 EGFR are downstream target genes miR-493-5p. inhibits EMT via AKT/GSK-3β/Snail signaling cancer. Taken together, our study identified CREB1, establish regulatory loop which could prove useful development effective therapies against
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