P2U purinoceptors: cDNA cloning, signal transduction mechanisms and structure-function analysis.
作者： Kevin D. Lustig , Gary A. Weisman , John T. Turner , Richard Garrad , Andrew K. Shiau
DOI: 10.1002/9780470514900.CH11
关键词:
摘要: The cloning of a P2U purinoceptor cDNA has made it possible to use molecular biological approaches investigate function. Expression recombinant purinoceptors in mammalian cells lacking endogenous enabled us characterize the receptor protein and its downstream effectors, allowed partial analysis role certain amino acid residues ligand binding. These have placed pharmacological classification on firm footing generated model systems that can be used receptor-ligand binding, regulation signal transduction.
sci-hub.st 参考文章(26)
G. R. Dubyak, C. el-Moatassim, Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides American Journal of Physiology-cell Physiology. ,vol. 265, ,(1993) , 10.1152/AJPCELL.1993.265.3.C577
B B Fredholm, G Burnstock, M P Abbracchio, K A Jacobson, M Williams, P Leff, J W Daly, T K Harden, NOMENCLATURE AND CLASSIFICATION OF PURINOCEPTORS Pharmacological Reviews. ,vol. 46, pp. 143- 156 ,(1994)
J L Gordon, Extracellular ATP: effects, sources and fate. Biochemical Journal. ,vol. 233, pp. 309- 319 ,(1986) , 10.1042/BJ2330309
Stuart F. J. GRICE, Fiona GRUNINGER-LEITCH, Rapid purification of homodimer and heterodimer HIV-1 reverse transcriptase by metal chelate affinity chromatography. FEBS Journal. ,vol. 187, pp. 307- 314 ,(1990) , 10.1111/J.1432-1033.1990.TB15306.X
M. Simon, M. Strathmann, N. Gautam, Diversity of G proteins in signal transduction. Science. ,vol. 252, pp. 802- 808 ,(1991) , 10.1126/SCIENCE.1902986
WILLIAM C. PROBST, LENORE A. SNYDER, DAVID I. SCHUSTER, JÜRGEN BROSIUS, STUART C. SEALFON, Sequence alignment of the G-protein coupled receptor superfamily. DNA and Cell Biology. ,vol. 11, pp. 1- 20 ,(1992) , 10.1089/DNA.1992.11.1
L. Erb, K. D. Lustig, D. M. Sullivan, J. T. Turner, G. A. Weisman, Functional expression and photoaffinity labeling of a cloned P2U purinergic receptor. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 10449- 10453 ,(1993) , 10.1073/PNAS.90.22.10449
Eric A. Barnard, Geoffrey Burnstock, Tania E. Webb, G protein-coupled receptors for ATP and other nucleotides: a new receptor family Trends in Pharmacological Sciences. ,vol. 15, pp. 67- 70 ,(1994) , 10.1016/0165-6147(94)90280-1
Steve E. O'Connor, Ian A. Dainty, Paul Leff, Further subclassification of ATP receptors based on agonist studies Trends in Pharmacological Sciences. ,vol. 12, pp. 137- 141 ,(1991) , 10.1016/0165-6147(91)90530-6
Tai-An Lin, Kevin D. Lustig, Michael G. Sportiello, Gary A. Weisman, Grace Y. Sun, Signal transduction pathways coupled to a P2U receptor in neuroblastoma × glioma (NG108-15) cells Journal of Neurochemistry. ,vol. 60, pp. 1115- 1125 ,(1993) , 10.1111/J.1471-4159.1993.TB03262.X