Multidimensional effects of biologically synthesized silver nanoparticles in Helicobacter pylori , Helicobacter felis , and human lung (L132) and lung carcinoma A549 cells

摘要: Silver nanoparticles (AgNPs) are prominent group of nanomaterials and recognized for their diverse applications in various health sectors. This study aimed to synthesize the AgNPs using leaf extract Artemisia princeps as a bio-reductant. Furthermore, we evaluated multidimensional effect biologically synthesized Helicobacter pylori, felis, human lung (L132) carcinoma (A549) cells. UV-visible (UV–vis) spectroscopy confirmed synthesis AgNPs. X-ray diffraction (XRD) indicated that specifically indexed crystal structure. The results from Fourier transform infrared (FTIR) indicate biomolecules involved stabilization Dynamic light scattering (DLS) studies showed average size distribution particle between 10 40 nm, transmission electron microscopy (TEM) were significantly well separated spherical with an 20 nm. caused dose-dependent decrease cell viability biofilm formation increase reactive oxygen species (ROS) generation DNA fragmentation H. pylori felis. induced mitochondrial-mediated apoptosis A549 cells; conversely, had no significant effects on L132 this suggest could cause cell-specific mammalian Our findings demonstrate environmentally friendly method prepared have such anti-bacterial anti-biofilm activity against felis also cytotoxic cancer report describes comprehensively bacteria We believe will open new avenue towards biotechnological biomedical near future.