Interactions with the gamma-Aminobutyric Acid A-Receptor: Polychlorocycloalkanes and Recent Congeners

摘要: This chapter outlines the interactions with gamma-aminobutyric acid A (GABA)-receptor. GABA is principal neurotransmitter of mammalian and insect central nervous system (CNS) neuromuscular junction. In mammals, baclofen-sensitive B -receptors are coupled to calcium potassium channels action mediated by G-proteins. contrast, members super family ligand-gated ion that contain a chloride ionophore. Many chemicals found interact picrotoxinin binding site in -receptor ionophore highly toxic both mammals insects; studies radioligands have indicated differences between their receptors offer prospect selective toxicity involving this target. The human brain consists four or five 50–60 kDa glycoprotein subunits, each which contains (M1–M4) hydrophobic domains (alpha-helices) traverse membrane.