Benign monoclonal gammapathy

摘要: ABSTRACT The natural history of benign monoclonal gammapathy (BMG) has been followed by repeated studies patients with M components through periods up to two decades. disappearance an component is quite exceptional—in this material only once. Populations increase in IgG, IgA and IgM have studied separately. Slow, but steady, many years may be found without development myeloma (MM). Rapid transition from a steady state the progression rare usually, not always, indicates clearcut myeloma. Intermediate patterns are uncommon make it very difficult individual cases draw sharp line between that should treated observed. cause pain judge. Osteolytic foci skull usually diagnostic for MM, vertebral fracture also occur osteopenia. It evident period at least three close observation treatment routine. “Prophylactic” BMG cytostatic drugs never attempted.