Phospholipase A2 activation as a therapeutic approach for cognitive enhancement in early-stage Alzheimer disease.
作者： Evelin L. Schaeffer , Orestes V. Forlenza , Wagner F. Gattaz
DOI: 10.1007/S00213-008-1351-0
关键词:
摘要: Rationale Alzheimer disease (AD) is the leading cause of dementia in elderly and has no known cure. Evidence suggests that reduced activity specific subtypes intracellular phospholipases A2 (cPLA2 iPLA2) an early event AD may contribute to memory impairment neuropathology disease.
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Martín Cammarota, Miguelina Levi de Stein, Gustavo Paratcha, Lia R. M. Bevilaqua, Iván Izquierdo, Jorge H. Medina, Rapid and transient learning-associated increase in NMDA NR1 subunit in the rat hippocampus. Neurochemical Research. ,vol. 25, pp. 567- 572 ,(2000) , 10.1023/A:1007590415556
Lakher M, Mauron C, Holbrook Pg, Blusztajn Jk, Tacconi M, Wurtman Rj, Maire Jc, Richardson Ui, Liscovitch M, "Autocannibalism" of membrane choline-phospholipids: physiology and pathology. Psychopharmacology Bulletin. ,vol. 22, pp. 781- ,(1986)
Martín Cammarota, Gustavo Paratcha, Miguelina Levi de Stein, Ramón Bernabeu, Iván Izquierdo, Jorge H. Medina, B-50/GAP-43 phosphorylation and PKC activity are increased in rat hippocampal synaptosomal membranes after an inhibitory avoidance training Neurochemical Research. ,vol. 22, pp. 499- 505 ,(1997) , 10.1023/A:1027324214060
R.A. Nemenoff, S. Winitz, N.X. Qian, V. Van Putten, G.L. Johnson, L.E. Heasley, Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C. Journal of Biological Chemistry. ,vol. 268, pp. 1960- 1964 ,(1993) , 10.1016/S0021-9258(18)53948-X
Francesca Bosetti, Gayani R. Weerasinghe, The expression of brain cyclooxygenase-2 is down-regulated in the cytosolic phospholipase A2 knockout mouse. Journal of Neurochemistry. ,vol. 87, pp. 1471- 1477 ,(2003) , 10.1046/J.1471-4159.2003.02118.X
Kenneth R. Bundell, Lynne Douglas, John Morten, Maurice Needham, Robert D. Gordon, Ian A. Leighton, David G. Campbell, Philip Cohen, Ann Creaney, David C. Wilton, David J. Masters, Graham A. F. Ritchie, Richard Mott, Ian W. F. Taylor, Cloning and Expression of Cytosolic Phospholipase A2 (cPLA2) and a Naturally Occurring Variant FEBS Journal. ,vol. 238, pp. 690- 697 ,(1996) , 10.1111/J.1432-1033.1996.0690W.X
Michelle V Winstead, Jesús Balsinde, Edward A Dennis, Calcium-independent phospholipase A2: structure and function Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. ,vol. 1488, pp. 28- 39 ,(2000) , 10.1016/S1388-1981(00)00107-4
Marc-André Martel, Christian Patenaude, Caroline Ménard, Stéphanie Alaux, Brian S. Cummings, Guy Massicotte, A novel role for calcium-independent phospholipase A2 in α-amino-3-hydroxy-5-methylisoxazole-propionate receptor regulation during long-term potentiation European Journal of Neuroscience. ,vol. 23, pp. 505- 513 ,(2006) , 10.1111/J.1460-9568.2005.04565.X
E.A. Dennis, Diversity of group types, regulation, and function of phospholipase A2. Journal of Biological Chemistry. ,vol. 269, pp. 13057- 13060 ,(1994) , 10.1016/S0021-9258(17)36794-7
Elizabeth Gould, Anna Beylin, Patima Tanapat, Alison Reeves, Tracey J. Shors, Learning enhances adult neurogenesis in the hippocampal formation. Nature Neuroscience. ,vol. 2, pp. 260- 265 ,(1999) , 10.1038/6365