作者: Kathryn Whitehead , Natalie Karr , Samir Mitragotri
DOI: 10.1007/S11095-007-9488-9
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摘要: Purpose The use of intestinal permeation enhancers to overcome the absorption challenges associated with oral drug delivery has been hampered by notion that enhancer efficacy is directly linked toxicity. This study attempts gain insight into principles governing potency and toxicity behavior enhancers.