Method for simultaneously extracting the input function and pharmacokinetic parameters of an active ingredient

作者: Segolene De Gavriloff , Renaud Maroy

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摘要: This extraction method in a structure of living organism from measurement image the kinetics active ingredient comprising plurality regions interest inside each which are measured, comprises following steps: determining ( 30 ) sets kinetics, determined being different other and set including several measured kinetics; defining 32 at least one kinetic model, parameters defined model formed by input function pharmacokinetic parameters; estimating 34 resolving deducing 36 final parameters.

参考文章(8)
David Atkinson, Andrew Melbourne, Image registration method ,(2008)
Ravindra Mohan Manjeshwar, Simulation of nuclear medical imaging ,(2003)
Nancy A. Monteiro-Riviere, Jim E. Riviere, Xin-Rui Xia, Ronald E. Baynes, Method and apparatus for determining a molecular descriptor of absorption for a candidate compound ,(2003)
R. Maroy, R. Boisgard, C. Comtat, V. Frouin, P. Cathier, E. Duchesnay, F. Dolle, P.E. Nielsen, R. Trebossen, B. Tavitian, Segmentation of Rodent Whole-Body Dynamic PET Images: An Unsupervised Method Based on Voxel Dynamics IEEE Transactions on Medical Imaging. ,vol. 27, pp. 342- 354 ,(2008) , 10.1109/TMI.2007.905106
Dagan Feng, Koon-Pong Wong, Chi-Ming Wu, Wan-Chi Siu, A technique for extracting physiological parameters and the required input function simultaneously from PET image measurements: theory and simulation study international conference of the ieee engineering in medicine and biology society. ,vol. 1, pp. 243- 254 ,(1997) , 10.1109/4233.681168
Torfinn Taxt, Renate Gruner, Method of perfusion imaging ,(2007)