Progressive retinal structure abnormalities in multiple system atrophy

摘要: Background Objective measures of disease progression that can be used as endpoints in clinical trials MSA are necessary. We studied retinal thickness patients with and assessed changes over time to determine its usefulness an imaging biomarker progression. Methods This was a cross-sectional study including 24 MSA, 20 PD, 35 controls, followed by longitudinal 13 patients. Patients were evaluated high-definition optical coherence tomography the Unified Multiple System Atrophy Rating Scale. Evaluations performed at baseline consecutive follow-up visits for up 26 months. Results MSA subjects had normal visual acuity color discrimination. Compared nerve fiber layer (P = 0.008 P 0.001) ganglion cell complex 0.013 thicknesses reduced PD. No significant differences between PD found. Over time, there reduction thicknesses, estimated annual average losses 3.7 1.8 μm, respectively. Conclusions Visually asymptomatic exhibit progressive reductions and, lesser extent, macular complex, which quantified tomography. Specific patterns damage could useful future trials. © 2015 International Parkinson Movement Disorder Society