Mitochondrial DNA Measurement in Exfoliated Cells for Cancer Detection and Monitoring: The Copy Number Advantage

摘要: Mitochondrial genetic alterations are demonstrated in several primary tumors, and efforts by many investigators indicate tumor specific mtDNA mutations can be detected bodily fluids. Prostate liver cancer, as well melanoma SNP detectable whole blood serum. Additionally, circulating mitochondrial nucleic acids (DNA RNA) measured of prostate testicular cancer patients. Importantly, such materials have prognostic utility. The high copy number genome tissues enables easy measurement biofluids saliva, sputum or BAL, nipple aspirate fluids urine. When that mutation load is indicative cellular progression towards malignancy, measurements will enable early detection. This chapter examines the clinical applications