Mild Exercise Reduces Cerebral Vasospasm After Aneurysm Subarachnoid Hemorrhage: A Retrospective Clinical Study and Correlation with Laboratory Investigation

摘要: Background: Aneurysmal subarachnoid hemorrhage (SAH) is a leading cause of death and disability often complicated by cerebral vasospasm (CV). Conventional management to prevent CV includes bedrest; however, inactivity places the patient at risk for nonneurological complications. We investigated effect mild exercise after SAH in clinical laboratory settings. Methods: Clinical: Data from 80 patients with were analyzed retrospectively. After aneurysms secured, physical therapy was initiated as tolerated. complications compared timing active therapy. Laboratory: 18 Rodents divided into three groups: (1) control, (2) without exercise, (3) plus exercise. On day 5, brainstems removed injury marker inducible nitric oxide synthase (iNOS). Results: Mild before 4 significantly lowered incidence symptomatic nonexercised group. There no difference additional based upon Staining iNOS higher group than control group, but there between exercised groups, confirming that did not promote neuronal injury. Conclusion: Early mobilization reduced CV. The relationship should be studied further prospective trial defined regimens.