Recombinant microorganisms and uses therefor

作者: Wendy Chen , Michael Koepke , None

DOI:

关键词:

摘要: Bacteria are genetically engineered to produce 3-hyrdoxypropionate (3-HP). The bacteria carboxydotrophic acetogens. acetyl-coA using the Wood-Ljungdahl pathway for fixing CO/C0?2#191. A malonyl-coA reductase from a bacterium that contains such an enzyme is introduced. Additionally, carboxylase may also be introduced production of 3-HP can improved by overproduction acetyl-CoA or biotin. This effected promoters higher copy number enzymes catalytically more efficient.

参考文章(125)
Arnim Wiezer, Sandra Hujer, Peter Dürre, Michael Köpke, Heiko Liesegang, Wolfgang Liebl, Claudia Held, Gerhard Gottschalk, Armin Ehrenreich, Antje Wollherr, Correction for Clostridium ljungdahlii represents a microbial production platform based on syngas Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, ,(2010)
Christopher P. Mercogliano, Hans H. Liao, Michael D. Lynch, Tanya E.w. Lipscomb, Faith Dizon Watson, Compositions and methods regarding direct nadh utilization to produce 3-hydroxypropionic acid, derived chemicals and further derived products ,(2012)
Joseph Frank Sambrook, David William Russell, Molecular cloning : a laboratory manual Published in <b>2001</b> in Cold Spring Harbor NY) by Cold Spring Harbor laboratory. ,(2001)
正治 向山, Masaharu Mukoyama, Hiroshi Horikawa, 洋 堀川, Method for producing 3-hydroxypropionic acid ,(2011)
Klaas Jan Hellingwerf, Philipp Emmanuil Savakis, Jeroen Hugenholtz, Stephan Andreas Angermayr, Synthesis of acetoin, 2,3-butanediol and 2-butanol by cyanobacteria by heterologous expression of a catabolic pathway ,(2013)
Natalia Sedkova, Edward S. Miller, Manjari Singh, Dennis Flint, Tina K. Van Dyk, Vasantha Nagarajan, Michael G. Bramucci, Method for the production of 2-butanone ,(2008)