New Immunosuppressive Sphingoid Base and Ceramide Analogues in Wild Cordyceps
作者： Jia-Ning Mi , Yuwei Han , Yingqiong Xu , Junping Kou , Jing-Rong Wang
DOI: 10.1038/SREP38641
关键词:
摘要: A comprehensive identification of sphingoid bases and ceramides in wild Cordyceps was performed by integrating a sequential chromatographic enrichment procedure an UHPLC-ultrahigh definition-Q-TOF-MS based sphingolipidomic approach. total 43 303 were identified from Cordyceps, including 12 new base analogues 159 ceramide on high-resolution MS MS/MS data, isotope distribution, matching with the personal sphingolipid database, confirmation standards retention time rule. The immunosuppressive bioassay results demonstrated that fraction exhibits more potent activity than fraction, elucidating ingredients Cordyceps. This study represented most natural source. findings this provided insight into therapeutic application
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