Obstetric and neonatal outcome of pregnancies fathered by males on immunosuppression after solid organ transplantation.

摘要: Immunosuppressive drugs may influence spermatogenesis, but little is known about outcome of pregnancies fathered by transplanted males. We estimated risk adverse outcomes in (with data after the first trimester) males that had undergone organ transplantation and were treated with immunosuppression. A population-based study, linking from Norwegian transplant registry Medical Birth Registry Norway during 1967-2009 was designed. All men undergoing solid included. Odds ratios for major malformations, preeclampsia, preterm delivery (<37 weeks) small-for-gestational-age obtained using logistic regression. total 2463 males, fathering babies 4614 deliveries before 474 identified. The preeclampsia increased (AOR: 7.4, 95% CI: 1.1-51.4,) compared to prior transplantation. No found congenital malformations or other when general population (2 511 506 births). Our results indicate an mediated through immunosuppressed father. Importantly, no obstetric which reassure male recipients planning father children.